A clear oily sterile solution containing 0.2 mg Oestradiol Benzoate PhEur per ml.
Mesalin is indicated solely for the prevention of pregnancy following mismating (mesalliance) in the bitch.
0.01 mg/kg (0.5 ml/10 kg) to be given on the 3rd and 5th day after mating. A third dose may be administered 7 days after mating if circumstances dictate e.g. if the bitch has been observed to have been mated several times or where the timing of the unwanted mating is unknown.
Administer by subcutaneous or intramuscular injection. The product does not contain an antimicrobial preservative. Swab the septum prior to removal of each dose. Use a dry sterile needle and syringe.
Mesalin should not be administered to cats.
For animal treatment only. Keep out of reach of children.
Store below 25°C. Protect from light. Avoid the introduction of contamination during use.
At a low temperature the product may become viscous. Warming the vial in the hand will restore the contents to the normal state.
Following withdrawal of the first dose use the product within 28 days. Discard unused material. Should any apparent growth or discolouration occur the product should be discarded.
POM.
5 ml vials.
Large doses of oestrogens have been associated in the dog with blood dyscrasias and pathological changes of the uterus. Mesalin has been formulated to facilitate the administration of a low but effective dose of oestradiol benzoate to help to minimise the occurrence of side effects.
Because the amount of oestrogen given to the bitches is low when Mesalin is used prolonged oestrus with the risk of further possibly fertile matings is largely avoided. False pregnancies pyometra and vaginal discharges are commonly seen after oestrus in normally cycling unmated bitches and may occur with similar frequency following the administration of Mesalin.
In trial work pregnancy was found to continue in up to 5% of bitches despite Mesalin treatment. It is suggested that owners are advised accordingly before the treatment is commenced.
Vm 01708/4246.